Yes. Solana is available through the public OpenSea API. Items, collections, events, listings, offers, swaps, and the order action endpoints all return Solana data, and solana is a valid chain in the API reference.
One limitation to plan around: the API can only fulfill orders created using OpenSea's own Solana marketplace program. Listings and offers created on other Solana marketplaces can be read through the API, but not fulfilled through it. Seaport specific endpoints remain Ethereum and EVM only.
For endpoint details and examples, see the OpenSea API documentation.